Chromosome Segregation: Reconstituting the Kinetochore
نویسندگان
چکیده
Faithful chromosome segregation is accomplished by attachment of chromosomes to spindle microtubules using the kinetochore. In a major step forward in understanding the functional and structural complexity of kinetochores, a 21-subunit human centromere - kinetochore complex has been reconstituted entirely from purified components, recreating the connection between DNA and microtubule.
منابع مشابه
Basic mechanism for biorientation of mitotic chromosomes is provided by the kinetochore geometry and indiscriminate turnover of kinetochore microtubules
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عنوان ژورنال:
- Current Biology
دوره 26 شماره
صفحات -
تاریخ انتشار 2016